Welcome to Institute of Genomics
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The CNRGH is the French national research center which enables a response to scientific questions necessitating high throughput sequencing and genotyping thanks to the development and deployment of innovative integrated technologies. The organization of the CNRGH enables optimization of genetic and genomic research on human diseases by creating indispensable links between cohort constitution (DNA samples), identification of the responsible genes, and study of the transcriptome and epigenome.
List of the main projects of the Institut de Génomique
The CNRGH laboratories
Team leader: Jean-François Deleuze
The Intermediate- and Low-Throughput Laboratory – Technological Development (LMBD) of the CNRGH has two major objectives: data production and technological development.
The Intermediate- and Low-Throughput Laboratory implements DNA and RNA sequencing projects and expression projects (microarray and real-time PCR) for which the number of samples is limited (from a few units to a few hundred units). The projects requiring processing of a large number of samples are assumed by the High-Throughput Laboratory.
For targeted sequencing, the Laboratory is equipped with a set of automated technical solutions (Agilent system, Perkin Elmer system, TAP), sequencers (NextSeq500, MiSeq, Proton, PGM, 454) and other instruments (iScan, MxPro, nanodrop, bioanalyzer, etc.).
The Laboratory makes use of the expertise of the DNA/RNA Biological Resources Laboratory of the CNRGH for the extraction, quality control and storage of biological specimens.
The data generated are analyzed in-house in cooperation with the Bioinformatics Laboratory and Quality Control team of the CNRGH.
The Laboratory is also responsible for testing new DNA and RNA analysis methods and conducts active technological monitoring in liaison with the various players in the sequencing field.
New sequencing approaches, new sequencers and new solutions for WES and targeted capture are tested, as are new protocols oriented toward small quantities and optimizations for degraded starting materials, DNA or RNA.
The LMBD works on projects in cooperation with French, European and international partners in various fields: neurodegeneration, cancer, rare diseases, inflammatory diseases, various human diseases, murine models of human diseases, etc.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.